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PE 22-28 10mg
Research Grade Peptide
- Research Grade
- 99% Purity
- Third-Party Verified
Reference Strength: 10mg
R599,00
Chemical Name / Amino Acid Sequence: GVSWGLR
Availability: In stock
SKU: PE10
PE 22-28 10mg
R599,00
PE-22-28 is a synthetic heptapeptide derived from the sortilin propeptide and investigated for its potential rapid antidepressant, neuroprotective and neuroplasticity-supporting properties.
Availability: In stock
Included with your purchase
Each qualifying product includes 3ml of 0.9% Benzyl Alcohol Bacteriostatic Water.
Complimentary Purchase Kit
Every qualifying vial includes a complimentary purchase kit at no additional cost.
Research Overview
About PE 22-28 10mg
PE-22-28 is a potent and selective TREK-1 potassium channel antagonist engineered from spadin-related research. Laboratory studies have explored its effects on neurogenesis, synaptic plasticity and mood-related pathways.
How It Works in Research
PE-22-28 selectively inhibits TREK-1 (KCNK2) potassium channels, increasing neuronal excitability and serotonergic signalling. Preclinical studies suggest activation of CaMKII/CREB pathways, increased BDNF expression, enhanced hippocampal neurogenesis and synaptogenesis, with greater potency than spadin in laboratory models.
Research Applications
• Mood regulation • Neuroplasticity • Neurogenesis • Neuroprotection • Cognitive function • Stress resilience
Researchers study PE-22-28 because it may promote brain plasticity, neuronal resilience and mood regulation through selective TREK-1 inhibition.
Product Specifications
- Product Name: PE-22-28
- Reference Strength: 10 mg
- Amino Acid Sequence: GVSWGLR
- Appearance: White to off-white lyophilised powder
Research Information
- Purity Standard: ≥98% (HPLC)
- Category: Synthetic heptapeptide
- Reconstitution: 3.0 mL bacteriostatic water
- Final Concentration: 3.33 mg/mL
- Storage: 2–8°C after reconstitution
Mechanism of Action
PE-22-28 selectively inhibits TREK-1 (KCNK2) potassium channels, increasing neuronal excitability and serotonergic signalling. Preclinical studies suggest activation of CaMKII/CREB pathways, increased BDNF expression, enhanced hippocampal neurogenesis and synaptogenesis, with greater potency than spadin in laboratory models.
Potential Benefits in Research
Rapid antidepressant-like effects in preclinical models.
- Enhanced hippocampal neurogenesis and synaptic plasticity.
- Support for BDNF expression and neuronal survival.
- Neuroprotective effects in experimental stroke models.
- Favorable selectivity without observed cardiac or metabolic effects in preclinical studies.
Safety Profile
Rapid antidepressant-like effects in preclinical models.
- Enhanced hippocampal neurogenesis and synaptic plasticity.
- Support for BDNF expression and neuronal survival.
- Neuroprotective effects in experimental stroke models.
- Favorable selectivity without observed cardiac or metabolic effects in preclinical studies.
Research Applications
Mood regulation
Neuroplasticity
Neurogenesis
Neuroprotection
Cognitive function
Stress resilience
Human clinical dosing has not been established; this protocol is educational.
REFERENCE RECONSTITUTION INFORMATION
Goal: Support rapid neuroplasticity, mood regulation and neuroprotection through selective TREK-1 inhibition. Schedule: Daily subcutaneous injections for 12–16 weeks (8 weeks minimum). Dose Range: 50–200 mcg daily. Reconstitution: Add 3.0 mL bacteriostatic water to one 10 mg vial (~3.33 mg/mL).
Always follow sterile preparation techniques when handling research peptides.
Human clinical dosing has not been established; this protocol is educational.
General Preparation
• Use a new sterile insulin syringe for each injection. • Rotate injection sites daily. • Inject slowly and consistently. • Record dosing and injection sites. • Human clinical dosing has not been established; this protocol is educational.
- Slowly add bacteriostatic water down the inside wall of the vial. Allow the powder to dissolve naturally and gently swirl until clear. Do not shake vigorously.
PE-22-28 (10MG)- RECONSTITUTION TABLES
Reference Handling Information
Reference information for laboratory handling of PE 22-28 10mg.
- Schedule: Daily subcutaneous injections for 12–16 weeks (8 weeks minimum).
- Dose Range: 50–200 mcg daily. Reconstitute with 3.0 mL bacteriostatic water to achieve approximately 3.33 mg/mL. At this concentration, 1 U-100 unit (0.01 mL) delivers approximately 33.3 mcg.
Reference Parameters (Dosing Protocol)
| Week | Daily Dose | U-100 Units | Volume |
|---|---|---|---|
| Weeks 1–2 | 50 mcg | 1.5 units | 0.015 mL |
| Weeks 3–8 | 100 mcg | 3 units | 0.03 mL |
| Weeks 9–12 (Optional) | 150 mcg | 4.5 units | 0.045 mL |
| Weeks 13–16 (Optional) | 200 mcg | 6 units | 0.06 mL |
For laboratory research only.
Experimental Study Period
STUDY PERIOD
12–16 weeks (8 weeks minimum).
RESEARCH CONTEXT
Support rapid neuroplasticity, mood regulation and neuroprotection through selective TREK-1 inhibition.
Daily subcutaneous injections for 12–16 weeks (8 weeks minimum).
View Certificate of Analysis
View Certificate of Analysis Each batch of PE-22-28 is independently tested by third-party laboratories. Download the Certificate of Analysis to verify purity, identity, and quality.
99%
Verified Purity
3rd Party
Lab Tested
Certified
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FOR RESEARCH PURPOSES ONLY
This product is intended for research and laboratory use only. Always consult qualified researchers and follow appropriate safety protocols.
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