| Weight | 0,05 kg |
|---|
N-Acetyl Semax Amidate 10mg
Research Grade Peptide
- Research Grade
- 99% Purity
- Third-Party Verified
Reference Strength: 10mg
R820,00
CAS: 2920938-90-3
Formula: C39H54N10O10S
Molecular Weight: Approximately 855.0 g/mol
Chemical Name / Amino Acid Sequence: Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH2
Availability: In stock
SKU: NA-XA10
R820,00
N-Acetyl Semax Amidate (NA-Semax Amidate) is a terminally modified analogue of Semax. It retains the Semax core sequence while adding N-terminal acetylation and C-terminal amidation, producing Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH2 (Ac-MEHFPGP-NH2). Research interest centres on neurotrophic signalling, cognition, learning and memory, neuroprotection and peptide stability.
Availability: In stock
Included with your purchase
Each qualifying product includes 3ml of 0.9% Benzyl Alcohol Bacteriostatic Water.
Complimentary Purchase Kit
Every qualifying vial includes a complimentary purchase kit at no additional cost.
Research Overview
About N-Acetyl Semax Amidate 10mg
Semax is a synthetic heptapeptide based on the ACTH(4-7) sequence with a C-terminal Pro-Gly-Pro extension. N-Acetyl Semax Amidate preserves the seven-amino-acid Semax core while chemically modifying both termini.N-terminal acetylation and C-terminal amidation are established peptide-chemistry strategies used to alter terminal charge and potentially reduce susceptibility to exopeptidase degradation.The modified compound is chemically catalogued as a distinct molecule, but the peer-reviewed literature is concentrated overwhelmingly on standard Semax. The strongest Semax research includes studies of BDNF, NGF, Trk receptors, learning and memory, and experimental neuroprotection.
How It Works in Research
The best-characterized mechanisms come from parent Semax research. Semax has been shown in animal studies to alter the expression of neurotrophic factors including brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF).Neurotrophins are signalling proteins involved in neuronal survival, plasticity, learning and adaptation.In rat hippocampal research, Semax increased BDNF protein levels and TrkB phosphorylation, together with changes in BDNF and TrkB gene expression. TrkB is a principal receptor through which BDNF transmits cellular signals. These findings have supported the hypothesis that Semax-related cognitive effects may involve modulation of the BDNF/TrkB system.N-Acetyl Semax Amidate adds an acetyl group to the N-terminus and an amide to the C-terminus. These terminal modifications provide a plausible peptide-design strategy for altering resistance to enzymatic breakdown.
Research Applications
BDNF and TrkB signalling • NGF and other neurotrophin pathways • Learning and memory research • Attention and cognitive signalling • Neuronal survival and neuroprotection • Experimental cerebral-ischemia models • Synaptic plasticity • Peptide stability and terminal modification • Comparison with standard Semax
Standard Semax is a seven-amino-acid peptide studied for brain and neurotrophic signalling. N-Acetyl Semax Amidate uses the same core peptide but chemically protects both ends of the molecule.The aim of these modifications is to create a more degradation-resistant research analogue. The frequently discussed BDNF, NGF, cognition and neuroprotection mechanisms come mainly from studies of standard Semax.
Product Specifications
- Product Name: N-Acetyl Semax Amidate
- Alternate Names: NA-Semax Amidate / N-Acetyl Semax
- CAS Number: 2920938-90-3
- Sequence: Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH2
- Short Sequence: Ac-MEHFPGP-NH2
- Molecular Formula: C39H54N10O10S
- Molecular Weight: Approximately 855.0 g/mol
Research Information
- Reference Strength: 10 mg
- Appearance: White to off-white solid
- Category: Modified neuroregulatory heptapeptide / Semax analogue
- Terminal Modifications: N-terminal acetylation; C-terminal amidation
- Research Focus: Neurotrophic signalling, cognition, neuroprotection and peptide stability
Mechanism of Action
The best-characterized mechanisms come from parent Semax research. Semax has been shown in animal studies to alter the expression of neurotrophic factors including brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF).Neurotrophins are signalling proteins involved in neuronal survival, plasticity, learning and adaptation.In rat hippocampal research, Semax increased BDNF protein levels and TrkB phosphorylation, together with changes in BDNF and TrkB gene expression.N-Acetyl Semax Amidate adds an acetyl group to the N-terminus and an amide to the C-terminus. These terminal modifications provide a plausible peptide-design strategy for altering resistance to enzymatic breakdown.
Key Research Characteristics
Modified Semax heptapeptide • Sequence: Ac-MEHFPGP-NH2 • N-terminal acetylation • C-terminal amidation • Research interest in BDNF, NGF and Trk signalling • Parent Semax studied in learning, memory and neuroprotection models • Direct evidence for the doubly modified analogue remains limited
Potential Benefits in Research
Parent Semax has been associated with increased BDNF protein and altered BDNF/TrkB signalling in animal research.
Semax has produced rapid changes in BDNF and NGF gene expression in several rat brain regions.
Experimental studies have investigated Semax in learning, memory and conditioned-response models.
Semax and its Pro-Gly-Pro fragment have been studied for neurotrophin-related transcription after experimental cerebral ischemia.
Terminal acetylation and amidation provide a rationale for studying altered peptide stability.
These findings do not establish clinical efficacy of N-Acetyl Semax Amidate itself.
Safety Profile
Possible local irritation with injectable research preparations.
Neurological or subjective effects may vary with exposure and individual sensitivity.
The modified analogue should not automatically be assumed to have the same pharmacokinetics as standard Semax.
Claims of a specific longer half-life, superior BBB penetration or greater potency require direct evidence.
Identity, purity and formulation should be confirmed against the batch COA.
Research Applications
BDNF and TrkB signalling • NGF and other neurotrophin pathways • Learning and memory research • Attention and cognitive signalling • Neuronal survival and neuroprotection • Experimental cerebral-ischemia models • Synaptic plasticity • Peptide stability and terminal modification • Comparison with standard Semax
Do not state a specific extended half-life, superior BBB penetration or superior potency unless future direct evidence supports those claims.
REFERENCE RECONSTITUTION INFORMATION
Research Goal: Investigate the modified Semax analogue in neurotrophic, cognitive and peptide-stability research.Reference Strength: 10 mg vial.Supplied Reference Dilution: 3.0 mL bacteriostatic water.Calculated Concentration: approximately 3.33 mg/mL.Supplied Educational Dose Range: 0.20-0.80 mg.Supplied Schedule: staged over 6 weeks.
Always follow sterile preparation techniques when handling research peptides.
Supplied educational framework for a 10 mg vial. All peptide doses are expressed in mg.
General Preparation
At this concentration, 1 unit on a U-100 syringe corresponds mathematically to approximately 0.0333 mg.
- Reference dilution: 10 mg + 3.0 mL bacteriostatic water = approximately 3.33 mg/mL.
- Lyophilized research material: keep sealed and protected from moisture.
- Research-supplier reference: powder at -20 °C for approximately 1 year or -80 °C for approximately 2 years.
- Research stock solutions are commonly stored frozen and protected from repeated freeze-thaw cycles.
- The supplied 3.0 mL BAC-water framework is an educational preparation convention, not a published formulation-stability study.
- Exact storage after preparation should follow formulation-specific and batch-specific validated stability information.
N-Acetyl Semax Amidate (10mg) - RECONSTITUTION TABLES
Reference Handling Information
Reference information for laboratory handling of N-Acetyl Semax Amidate 10mg.
- 5 days on / 2 days off educational framework.
Reference Parameters (Dosing & Reconstitution Guide)
| Stage | Target Dose | BAC Water | Volume | U-100 Units | 5-Day Weekly Total |
|---|---|---|---|---|---|
| Weeks 1-2 - Low / Starting | 0.50 mg | 3.0 mL | 0.15 mL | 15 units | 2.5 mg/week |
| Weeks 3-4 - Moderate | 0.75 mg | 3.0 mL | 0.23 mL | 23 units | 3.75 mg/week |
| Weeks 5-6 - Advanced | 1.0 mg | 3.0 mL | 0.30 mL | 30 units | 5.0 mg/week |
For laboratory research only.
Experimental Study Period
STUDY PERIOD
5 days
WASHOUT PERIOD
5 days
RESEARCH CONTEXT
2 days
For catalogue consistency, the supplied dose stages can be displayed using a 5-days-on / 2-days-off educational framework.
View Certificate of Analysis
View Certificate of Analysis Each batch of N-Acetyl Semax Amidate is independently tested by third-party laboratories. Download the Certificate of Analysis to verify purity, identity, and quality.
99%
Verified Purity
3rd Party
Lab Tested
Certified
Quality Assured
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FOR RESEARCH PURPOSES ONLY
This product is intended for research and laboratory use only. Always consult qualified researchers and follow appropriate safety protocols.
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